Pharmaceutical Chemistry I

This is the first of the two pharmaceutical chemistry course units and it discusses drug standardization and drug quality, drug quality assurance, inorganic pharmaceutical chemistry, and the chemistry of organic pharmaceuticals. Emphasis is placed on synthesis, structure-activity relationships, analysis, and storage of these types of drugs.

PURPOSE OF THE COURSE

This course exposes the students to practical concepts of pharmaceutical quality assurance. It also enables them to understand the synthesis and analysis of inorganic pharmaceutical drugs. It further enables them to appreciate the synthesis and structure-activity relationships (SAR) of organic pharmaceutical drugs. 

EXPECTED LEARNING OUTCOMES 

At the end of this course, the student is expected to:

1.    List the various compendia used for controlling the quality of pharmaceutical products

2.    State the possible sources of impurities in pharmaceuticals

3.    Describe the processes that lead to chemical and physical instability in pharmaceuticals

4.    Describe the process of standardization of active pharmaceutical ingredients and formulated products

5.    Describe the various limit tests in pharmaceutical chemistry

6.    Describe the physico-chemical properties of inorganic pharmaceutical preparations.

7.    Describe the production/synthesis, assay, identification and quality control of inorganic pharmaceutical preparations. 

8.    Outline the medical uses of inorganic pharmaceutical preparations.

9.    Describe the source, structure determination, classifications, synthesis, and structure-activity relationship of antibiotic, anti-neoplastic agents, anti-helminthic agents and antimalarials.