Principles Of Pharmaceutical Analysis
The course is highly practical oriented but also contains a substantial amount of lectures meant to introduce the student to the theory of various techniques used in the analysis of organic and inorganic compounds such as chromatography, mass spectrometry, UV/Vis spectroscopy, and atomic spectrophotometry.
This course enables the student to integrate knowledge of chemical structures of organic compounds and the principles of instrumental drug analysis. This in turn equips the student with knowledge and skills in quality control of medicines which can be applied in the pharmaceutical industry, research and development of new medicines, and drug regulation and quality control.
COURSE LEARNING OUTCOMES
At the end of this course, the students is expected to:
1. Identify the different chromophores present in organic compounds
2. Classify different spectrophotometric techniques used in the analysis of medicines
3. Describe the principles upon which the different spectrophotometric techniques work
4. Quantify a given drug using spectroscopic methods
5. Define chromatography and the various technical terms used in chromatographic techniques, such as mobile phase, stationary phase, retention time, resolution, peak symmetry, efficiency, selectivity, peak area normalization, internal/external standardization, etc.
6. State the main parts of an HPLC chromatograph and their key functions
7. Interprete the parts of a chromatogram and how it can be used to identify chemical substances
8. State the mobile phases used in the different modes of chromatography
9. Differentiate normal phase, reversed phase and hydrophilic interaction liquid chromatography
10. State the mobile phases and stationary phases employed in gas chromatography
11. Describe the basis of nuclear magnetic resonance (NMR) spectroscopy