Courses Catalogue

Biochemistry Ii

COURSE CODE: MCH 1203
COURSE CREDIT UNIT: 3
ACADEMIC PROGRAMME: Clinical Medicine and Community Health, Diploma
COLLEGE/SCHOOL/FACULTY: School of Allied Health Sciences
STATUS: Core
PROGRAMME TYPE: Undergraduate

Course Content and Outline

I) Lectures (30 Hours)

i) Bioenergetics and Biologic oxidation (4 hours)
a)      Concepts of bioenergetics in relation to thermodynamic principles as applied to the human system
b)      The electron transport system and oxidative phosphorylation
c)      Free radicals in health and disease

ii) Metabolism of Carbohydrates (6 hours)
a)      Digestion and absorption of carbohydrates (glucose Transporters)
b)      Glycolysis
c)      TCA cycle
d)     Gluconeogenesis
e)      Glycogen metabolism
f)       Inborn errors of carbohydrate metabolism  

iii) Metabolism of Lipids (6 hours)
a)      Lipid digestion and absorption
b)      Fatty acid oxidation
c)      Ketone body metabolism in health and disease
d)     Fatty liver and lipotropic factors
e)      Arachidonic acid derivatives-Prostaglandins and biochemical actions
f)       Lipoproteins classification and functions and disorders

iv) Metabolism of Amino acids/Proteins (6 hours)
a)      Digestion and absorption of proteins
b)      Glycogenic and Ketogenic amino acids
c)      Metabolism of proteins and amino acids
d)     Formation and disposal of ammonia- urea cycle
e)      Importance of products obtained from amino acids, e.g. Creatine, melatonin, Melanin, Epinephrine and porphyrins

 v) Metabolism of Nucleic acids (4 hours)
a)      Salvage biosynthesis of purines and pyrimidines
b)      Catabolism of purines and pyrimidines
c)      Disorders of Nucleic acids metabolism (Gout)

vi) Integration of metabolism (4 hours)
a)      Interrelationships of metabolites of carbohydrates
b)      Amino Acids and Lipids
c)      Fed-starve cycle
d)     Disorders of metabolism Diabetes
e)      Obesity
f)       Protein energy malnutrition (PEM)

II) Tutorials (10 Hours)
a)      Bioenergetics and biological oxidation(2 Hours)
b)      Carbohydrate metabolism(2 Hours)
c)      Lipid metabolism(2 Hours)
d)     Protein/Amino acid metabolism(2 Hours)
e)      Metabolism of nucleic acids (2 Hours)

II) Laboratory practicals (30 Hours)
a)        Determination of glucose in clinical samples
b)        Determination of serum cholesterol
c)        Determination of Serum Bilirubin
d)       Liver function Tests: AST, ALT, GGT, ALP
e)        Urine analysis-Dipstick

Teaching-learning methods
a)      Lectures
b)      Tutorials
c)      Group discussions
d)     Laboratory practical

Teaching-Learning materials
a)      White board and Markers
b)      LCD Projectors
c)      Posters and Models
d)     Biochemistry laboratory
e)      Clinical chemistry test kits

Teaching/Learning materials
a)      Biochemistry laboratory equipments
b)      Biochemistry  practical Log books
c)      Biochemistry text Books
d)     CD projectors
e)      Physiology Charts/models