Courses Catalogue

Basic Pharmacology

COURSE CODE: CMP 2102
COURSE CREDIT UNIT: 3
ACADEMIC PROGRAMME: Clinical Medicine and Community Health, Diploma
COLLEGE/SCHOOL/FACULTY: School of Allied Health Sciences
STATUS: Core
PROGRAMME TYPE: Undergraduate

Course Content and Outline

I) Lectures (35 Hours)

i) Introduction to pharmacology (1 Hour)

Definitions and basic concepts in Pharmacology

ii) Routes of drug administration (2 Hours)
a)      Enteral routes of drug administration; Their merits and demerits
b)      Parenteral routes of drug administration; Their merits and demerits
c)      Topical routes of drug administration; Their merits and demerits

iii)       Pharmacodynamics (6 Hours)
a)        Definitions and basic concepts
b)        Signal transduction in cells as basis of drug action
c)        Receptors and Drug-Receptor interactions
d)       Dose-Response relationships
e)        The concepts of potency, efficacy, full and partial agonists
f)         Drug antagonism
g)        Relation between drug dose and clinical response
h)        Concepts of Tolerance and drug dependence

iv)       Introduction to basic principles of pharmacokinetics (5 Hours)
a)        Definition of terms in pharmacokinetics
b)        Drug absorption and factors affecting drug absorption
c)        Drug distribution and factors affecting drug distribution
d)       Drug metabolism and factors affecting drug metabolism
e)        Drug excretion and factors affecting drug excretion

v)         Adverse drug reactions and Pharmacogenetics (4 Hours)
a)        Definition of terms
b)        Classification of adverse drug reactions
c)        Influence of genetic variability to response to drugs
d)       Examples of genetic disorders influencing response to drugs

vi)       Autonomic nervous system pharmacology (2 Hours)
a)        Review of Anatomy and Physiology of Autonomic Nervous system
b)        Principles of neurotransmission with emphasis on relation to action of drugs

vii)     Drugs affecting the cholinergic system (3 Hours)
a)        Cholinergic neurotransmission
b)        Cholinergic receptors
c)        Cholinergic agonists and antagonists

viii)   Drugs affecting the adrenergic system (4 Hours)
a)        Noradrenergic neurotransmission
b)        Adrenergic receptors
c)        Adrenergic agonists and antagonists

ix)       Autacoid pharmacology (8 Hours)
a)      Histamine: agonists and antagonists
b)      5-Hydroxytryptamine (Serotonin)
c)      The Eicosanoids
d)     Kinins and cytokines
e)      The Renin angiotensin aldosterone system
f)       Nitric oxide

II) Practicals (30 Hours)
a)      Laboratory rules and regulations
b)      Demonstration of the principle of physiological antagonism
c)      Measurement of the analgesic potency of test compounds using the acetic acid – induced writhing test
d)     Determination of acute toxicity of a test compound by Lorke‟s method
e)      Dose –response effects in anaesthetics
f)       Bio-availability of drugs
g)      Excretion of drugs in urine

 Teaching/learning methods
a)      Lectures/Overviews;
b)      Tutorials and Seminars;
c)      Laboratory practicals
d)     In-vivo practicals using laboratory animals.

Teaching/learning materials
a)      Pharmacological equipment
b)      Drug specimens
c)      LCD projectors