Courses Catalogue

Hematology

COURSE CODE: CMH 2204
COURSE CREDIT UNIT: 2
ACADEMIC PROGRAMME: Clinical Medicine and Community Health, Diploma
COLLEGE/SCHOOL/FACULTY: School of Allied Health Sciences
STATUS: Core
PROGRAMME TYPE: Undergraduate

Course Content and Outline

I) Lectures (20 Hours)

i) Normal Hematological system (6 Hours)
a)      Haemopoiesis: eryropoiesis, hemoglobin, metabolism of nutritional factors in production and function of erythrocytes (especially iron, vitamin B 12 and folate), erythrocyte function leucopoiesis, function of leucocytes, thrombopoiesis and function of platelets.
b)      Lymph reticular system, spleen function and role
c)      Haemostatis: Normal haemostatic function, role of platelets and vessel endothelium, coagulation factors, fibrinolysis, natural inhibitors of coagulation and Laboratory evaluation of blood coagulation.
d)     Blood groups and blood group serology especially ABO, Rhesus blood groups, significance of blood groups, Blood transfusion service.

ii) Disorders of red blood cell (7 Hours)

iii)Benign leucocyte disorders(2 Hours)
a)Anaemias:Disoders  of iron metabolism: iron deficiency, iron overload states, megaloblastic anaemia, deficiency of Vitamin B 12 and folate, Hemolytic anemias, haemoglobinopathies (especially sickle cell), membraneopathies, enzymopathies and extra corpuscular causes (e.g. immune heamolytic anaemias, parasitic causes, mechanical fragmentation), Anaemia of chronic disease: Bone marrow failure a plastic anaemia, pure red cell aplasia, Hypersplenism, laboratory evaluation. b)Polycythaemias.

iv)Hematology of HIV /AIDS(1 Hour)
Leucopenia: Hereditary and acquired causes, reactive leukoctosis,  d)Disorders of haemostatis and coagulation(4 Hours)
a)      Hereditary disorders (especially Haemophilias)
b)      Acquired disorders of haemostatis (especially idiopathic thrombocytopenic purpura, liver disease, disseminated intravascular coagulation)
c)      Thrombotic disorders.
d)     Anticoagulant and thrombolytic agents and their control.
e)      Principles of investigation of a haemostatic disorder.

v) Neoplastic disorders (2 Hours)
a)      A cute leukaemias- acute lymphoblastic leukemia, acute myeloid leukemia.
b)      Chronic myeloproliferative disorders- chronic myeloid leukemia, myelofibrosis, polycythaemia vera and essential throbocythaemia.
c)      Lymph proliferative disorders especially chronic lymphocytic leukemia, lymphoma, and multiple myeloma.


vi) Blood transfusion (3 Hours)

a)      Clinical indications and use of blood and blood components / products.
b)      Compatibility testing.
c)      Transfusion complications, investigations and management of transfusion reactions.

II) Practicals/Clinicals (15 Hours)

a)      PCV
b)      Blood films
c)      WBC estimation
d)     Coagulation tests
e)      ABO/Rh grouping

Teaching/learning methods

a)      Lectures
b)      Tutorials
c)      Course work
d)     Role-plays and simulation sessions
e)      Student presentations
f)       Directed and independent self-study
g)      Essay writing

Teaching/learning methods
a)  Whiteboard and markers
b)  LCD projector
c)  Disposable gloves
d)  Disposable syringes
e)   Microscope Slides
f)  Cover slips
g)   ESR tubes
h)  Grouping antisera
i)  EDTA bottlesHematocrit tubes