Publications

The role of the liver as a critical part of the immune system involved in both innateand adaptive immunity. As a major source of acute phase proteins, includingcomponents of the complement system. Hepatocytes are an important part ofinnate immunity and play an important role in controlling inflammatory responsesthroughout the body. Acute-phase protein production in hepatocytes is controlledby various cytokines released during the inflammatory process, with IL-6 and IL-1type cytokines acting as key regulators, cascading and synergistic regulation orit functions as a cascade network with inhibition. Effects on acute-phase proteinexpression. The pro inflammatory cytokine interleukin-6 is an endogenousbiochemical active during B cell maturation and inflammatory processes.Interleukin-6 plays an important role in regulating acute-phase protein synthesisin human hepatocytes.