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Sexually transmitted diseases (STDs) still remain a great public health problem of majorsignificance in most parts of the world. The incidence of acute STD is believed to be highamong sexually active adolescents worldwide due to changes and development in their lives.The study aims at establishing the attitude, knowledge and practices on STDS amongstudents studying at Kampala International University Western Campus in Ishaka town. Thestudy aims at establishing the attitude, knowledge and practices on STDS among studentsstudying at Kampala International University Western Campus in Ishaka town. A greatpercentage of anticipated respondents participated in this study making the response rate96%. Among these respondents (65%) were males and (35%) were females. The agedistribution of the respondents showed that most of the respondents (50%) were between 20-25 years old. Respondents (50%) were followers of the Catholic faith and followed otherreligions. The majority (76%) of the respondents were living near campus and (24%) of themare from rural areas. The majority of (60%) of respondents were single, and others were in arelationship. During the study period (70.9%) of the respondents were living in a hostel,(15.6%) were living in a rented house, and (13.5%) were living in another relative house. Mostof the respondents have knowledge about STIs, but there are still misconceptions and theirpractice remained quite low