Publications

Donepezil is the most common drug used in the treatment of disorders associated with memory loss, especially that inAlzheimer’s disease.Healthy individuals however have continued to use it as amemory enhancer. This studywas aimed at evaluatingthe combined therapy of donepezil and propolis on cognition in Drosophila melanogaster. Method. Drosophila melanogaster flieswere divided into five groups and fed with the different treatment doses of ethanolic extract of propolis and donepezil as follows:normal food, propolis 250 mg/mL, propolis 50 mg/mL, donepezil 0.001M, and donepezil 0.001M/propolis 50mg/mL added totheir food. The flies were fed from larval stage for 30 days. The memory and learning tests were conducted after every 10 daysto assess improvement with time. Results.The results obtained showed that the combination of propolis with donepezil caused aremarkable improvement in both the short- and long-termmemory. In addition, there was a dose dependent improvementwith theadministration of propolis. Conclusion. Propolis extract obtained from different parts of Uganda expressed cognitive improvementwhen coadministered with donepezil in wild type Drosophila melanogaster.