Publications

Previous investigations demonstrated that 6-gingerol-richfraction (6-GRF)preventedtesticular toxicity via inhibition of oxidative stress and endocrine disruption in CBZ-treatedrats. The influence of 6-GRFon alterations in histomorphometry and markerenzymes of testicular function in CBZ-treatedrats which hitherto has not been reportedwas investigated in this study. The animals were orally administered either CBZ(50 mg/kg) alone or in combination with 6-GRF(50, 100 and 200 mg/kg) for 14 consecutivedays. Histomorphormetric analysis demonstrated that 6-GRFsignificantlyprevented CBZ-mediatedincrease in the organo-somaticindex of the testes and seminiferoustubular diameter as well as the reduction in epithelium height and tubularlength of testes in the rats. Similarly, 6-GRFameliorated CBZ-induceddisruption in theepithelium height as well as in the proportion of tubule and interstitium of theepididymis the treated rats. Furthermore, 6-GRFprevented CBZ-mediatedincrease intesticular acid phosphatase activity and the decrease in testicular alkaline phosphatase,aminotransferases, glucose-6-phosphatedehydrogenase and lactate dehydrogenaseactivities. Moreover, 6-GRFameliorated CBZ-inducedreduction in the testicular andepididymal sperm count and sperm motility in the treated rats. Conclusively, 6-GRFenhances key functional enzymes involve in spermatogenesis and maintains histo-architectureof testes and epididymis in CBZ-treatedrats.