Publications

Malaria remains a significant global health threat, causing hundreds of thousands of deaths annually. Understandingthe host's protective mechanisms against this parasitic infection is crucial for developing effective prevention andtreatment strategies. Hepcidin, a central regulator of iron homeostasis, has emerged as a key player in the host'sdefense against malaria. This comprehensive review explores the multifaceted roles of hepcidin in safeguarding thehost from malaria infection. We delve into the molecular mechanisms of hepcidin regulation and its impact on theintricate interplay between iron, the immune system, and Plasmodium species. Additionally, we discuss the potentialtherapeutic implications of targeting hepcidin to enhance antimalarial responses. By shedding light on hepcidin'santimalarial arsenal, this review aims to contribute to the development of innovative strategies for combatingmalaria.