Publications

Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.

2023 School of Pharmacy IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY

Postprandial Hypolidaemic Effect of Aloe Vera Methanolic Extract via the Mechanism of Intestinal Pancreatic Lipase Enzyme Inhibition in Male Wistar Rats

1Faseun Yusuf Olusola, 2*Ezeonwumelu Joseph Obiezu Chukwujekwu, 3Odda John, 3Odoma Saidi, 4Idania Hidalgo, 5Moazzam Mohiuddin Lodhi, 6Patrick Maduabuchi Aja, 7Hambali Kaltume Umar, 6Mpumbya Jackie Rachael, 2Ebere Emilia Ayogu, 2Narayana Goruntla, 3Hope Onohuean and 8Ugwu Okechukwu Paul-Chima

This study explores the ability of Aloe vera, a traditional medicinal plant, to inhibit thedigestive enzyme pancreatic lipase and its potential impact on post-prandial lipidaemia inadult male Wistar rats. Aloe vera extract was administered in varying doses alongside oliveoil as a source of triglycerides. The study investigates the kinetics of post-prandial bloodtriglyceride concentration, Area Under the Curve (AUC) values, and the percentage inhibitionof pancreatic lipase. The results reveal significant inhibition of pancreatic lipase, indicatinga potential role in moderating post-prandial blood lipid levels. The inhibition type is suggested to be a mixed type, combining uncompetitive and competitive characteristics. Thisfinding suggests that Aloe vera may have therapeutic potential in managing conditionsrelated to post-prandial dyslipidaemia, such as diabetes.