Postprandial Hypolidaemic Effect of Aloe Vera Methanolic Extract via the Mechanism of Intestinal Pancreatic Lipase Enzyme Inhibition in Male Wistar Rats
This study explores the ability of Aloe vera, a traditional medicinal plant, to inhibit thedigestive enzyme pancreatic lipase and its potential impact on post-prandial lipidaemia inadult male Wistar rats. Aloe vera extract was administered in varying doses alongside oliveoil as a source of triglycerides. The study investigates the kinetics of post-prandial bloodtriglyceride concentration, Area Under the Curve (AUC) values, and the percentage inhibitionof pancreatic lipase. The results reveal significant inhibition of pancreatic lipase, indicatinga potential role in moderating post-prandial blood lipid levels. The inhibition type is suggested to be a mixed type, combining uncompetitive and competitive characteristics. Thisfinding suggests that Aloe vera may have therapeutic potential in managing conditionsrelated to post-prandial dyslipidaemia, such as diabetes.