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2023 School of Allied Health Sciences NEWPORT INTERNATIONAL JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES

Antioxidants and Pregnancy: Impact on Maternal and Fetal Health

Emmanuel Ifeanyi Obeagu1, Getrude Uzoma Obeagu2, Joseph Obiezu Chukwujekwu Ezeonwumelu3, Esther Ugo Alum4,5 and Okechukwu Paul- Chima Ugwu5

Pregnancy represents a physiological state characterized by increased metabolic demands and heightened oxidativestress, posing potential risks to both maternal health and fetal development. Oxidative stress, resulting from animbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms, has beenimplicated in various pregnancy complications such as preeclampsia, gestational diabetes, preterm birth, and fetaldevelopmental abnormalities. Antioxidants, a diverse group of compounds abundant in fruits, vegetables, and certainsupplements, play a pivotal role in neutralizing ROS and mitigating oxidative damage. This comprehensive reviewaims to elucidate the impact of antioxidants on maternal and fetal health during pregnancy. This paper underscoresthe crucial influence of antioxidants on fetal development. Antioxidants have shown promise in protecting fetal cellsand tissues from oxidative damage, potentially reducing the risk of adverse pregnancy outcomes, birth defects, andpreterm birth. In conclusion, while antioxidants exhibit potential benefits in mitigating oxidative stress and improving pregnancy outcomes, further research is warranted to elucidate optimal dosages, potential interactions,and long-term implications. This review offers insights into the current understanding of antioxidants in pregnancyand emphasizes their significance in promoting maternal well-being and optimal fetal development.Keywords: Antioxidants, Pregnancy, Maternal and Fetal Health