Publications

Immune hemolytic anemia (IHA) stands as a multifaceted hematologic disorder characterized by accelerateddestruction of red blood cells due to immune system dysregulation. This paper aims to elucidate the nuancedlandscape of IHA, focusing on its diverse diagnostic approaches and evolving treatment strategies. Diagnosticconsiderations encompass a range of laboratory tests, including direct and indirect Coombs tests, hemolysismarkers, and autoimmune antibody panels, elucidating their roles in confirming IHA etiology and subtypeclassification. Additionally, advancements in imaging modalities aid in identifying underlying causative factorscontributing to hemolysis. The paper further scrutinizes therapeutic interventions, spanning corticosteroids,immunosuppressive agents, and monoclonal antibodies, while also appraising emerging modalities likerituximab and splenectomy. Moreover, the role of supportive care and transfusion strategies in managing IHAassociatedcomplications is delineated. Challenges in IHA management, including refractory cases and adverseeffects of therapies, are deliberated alongside the potential of future advancements in precision medicine andtargeted therapies. By assimilating the latest diagnostic methodologies and treatment paradigms, this reviewprovides a comprehensive outlook on navigating the complexities of immune hemolytic anemia to optimizepatient care and outcomes.Keywords: haemolytic anaemia, anaemia, immunity, diagnosis, treatment