Publications

Persistent immune activation and chronic inflammation represent pivotal facets of HumanImmunodeficiency Virus (HIV) infection, profoundly influencing disease progression andcomplications. This abstract synthesizes current knowledge to unravel the intricate interplaybetween persistent immune activation, chronic inflammation, and their consequential impacton the development and exacerbation of anemia among individuals living with HIV. Persistentimmune activation and chronic inflammation are recognized hallmarks of HIV infection,contributing significantly to disease pathogenesis and complications. This paper aims toelucidate their intricate roles in perturbing erythropoiesis, leading to anemia, thushighlighting the pathophysiological mechanisms and clinical implications within the contextof HIV. Anemia, emerging as a consequence of persistent immune activation and chronicinflammation in HIV, bears significant clinical implications. Its association with diseaseprogression, treatment responses, and prognostic implications underscores its criticality inthe comprehensive care of HIV-infected populations. Persistent immune activation andchronic inflammation intricately contribute to the pathogenesis of anemia in HIV infection.Understanding their multifaceted roles in disrupting erythropoiesis holds promise fordeveloping targeted interventions and refining management strategies to alleviate anemiaburden among individuals living with HIV.Keywords: Immune Activation, Chronic Inflammation, Anemia, HIV