Publications

Acute appendicitis remains a common surgical emergency with challenges in prompt and accurate diagnosis.Serum biomarkers have garnered attention for their potential role in aiding diagnostic accuracy. This paper aimsto update the clinical implications of serum bilirubin and procalcitonin levels in diagnosing acute appendicitis.A systematic review of literature was conducted, encompassing studies that investigated the relationshipbetween serum bilirubin and procalcitonin levels and acute appendicitis. The search strategy included electronicdatabases, resulting in a comprehensive analysis of relevant articles. The findings suggest a notable associationbetween elevated serum bilirubin levels and the presence of acute appendicitis. Furthermore, procalcitoninexhibited promising diagnostic potential, demonstrating a significant correlation with the severity ofappendicitis. Subgroup analyses revealed varied sensitivity and specificity values, indicating the need for furtherrefinement in clinical application. The integration of serum biomarkers, specifically bilirubin and procalcitonin,into the diagnostic algorithms of acute appendicitis could potentially enhance the accuracy of clinicalassessments. However, limitations in existing studies, such as heterogeneity in patient populations and differingassay methodologies, emphasize the necessity for standardized protocols and larger prospective trials. Inconclusion, serum bilirubin and procalcitonin levels show promise as adjunctive tools in diagnosing acuteappendicitis. Their incorporation into clinical practice warrants careful consideration and validation throughlarger-scale studies to delineate their precise diagnostic utility, thereby potentially optimizing patient carepathways in the context of this prevalent surgical condition.Keywords : Acute appendicitis, Bilirubin, Procalcitonin, Diagnosis, Clinical implications