Publications

Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.

2024 School of Allied Health Sciences IDOSR JOURNAL OF APPLIED SCIENCES

Nutritional Approaches for Enhancing Immune Competence in HIV-Positive Individuals: A Comprehensive Review

Emmanuel Ifeanyi Obeagu1, Getrude Uzoma Obeagu2, Edward Odogbu Odo3, Matthew Chibunna Igwe4, Okechukwu Paul-Chima Ugwu5, Esther U. Alum5,6 and Puche Racheal Okwaja7

HIV/AIDS remains a significant global health challenge, characterized by compromised immune function that leadsto increased vulnerability to infections and other complications. Nutritional strategies have emerged as vitalcomponents in fortifying immune competence among individuals living with HIV. This review article provides acomprehensive analysis of diverse nutritional approaches aimed at reinforcing immune function in HIV-positiveindividuals. The paper delves into the impact of micronutrient supplementation, elucidating the effects of individualand combined micronutrients on immune response in HIV-positive individuals. Additionally, it discusses the role ofmacronutrients and various dietary patterns, such as the Mediterranean diet and DASH diet, in influencing immunefunction and overall well-being in this population. Furthermore, the article addresses the relevance of nutritionalstrategies in managing opportunistic infections commonly observed in PLWHA. Specific dietary considerations toprevent and mitigate these infections are explored, alongside the pivotal role of nutrition in supporting medicationadherence and efficacy. Recognizing the challenges faced by HIV-positive individuals, including food insecurity,malabsorption, and metabolic alterations, the review outlines potential barriers to implementing optimal nutritionalstrategies. Concluding remarks emphasize the critical importance of personalized and comprehensive nutritionalinterventions in managing HIV/AIDS and enhancing the quality of life for affected individuals. The articleunderscores the need for further research to refine nutritional guidelines and recommendations, enabling healthcareproviders and policymakers to offer tailored nutritional support to optimize immune function and overall health inHIV-positive populations.Keywords: HIV/AIDS, Immune function, Micronutrients, Macronutrients, Dietary patterns, Nutritionalstrategies.