Emmanuel Ifeanyi Obeagu1, Getrude Uzoma Obeagu2, Okechukwu Paul-Chima Ugwu3, Esther U. Alum3,4 and Jean Bosco Habimana5
Pregnancy is a physiologically demanding phase marked by profound changes that elevate oxidative stress levels,posing potential risks to maternal and fetal health. Oxidative stress, resulting from an imbalance between reactiveoxygen species (ROS) production and antioxidant defense mechanisms, has been implicated in various pregnancycomplications. Antioxidants, renowned for their ability to counteract ROS and mitigate cellular damage, haveemerged as a potential intervention to ameliorate adverse outcomes during pregnancy. The paper highlights thephysiological changes in pregnancy that contribute to heightened oxidative stress, emphasizing the link betweenoxidative stress and complications such as pre-eclampsia, gestational diabetes, preterm birth, and intrauterinegrowth restriction. This paper emphasizes the imperative for robust, well-designed clinical trials to elucidate theoptimal timing, dosages, and formulations of antioxidants in pregnancy. It calls for a comprehensive approach toestablish clear guidelines and recommendations for antioxidant supplementation. In conclusion, this reviewunderscores the potential of antioxidants as a promising intervention to mitigate oxidative stress-related pregnancycomplications. However, the inconclusive nature of current evidence necessitates further rigorous researchendeavors. Through this exploration, it accentuates the urgency for standardized protocols, ethical considerations,and extensive clinical studies to unlock the full potential of antioxidants in improving maternal and fetal healthoutcomes during pregnancy.Keywords: Antioxidants, Pregnancy, Maternal Health, Fetal Health, Oxidative Stress, Reactive Oxygen Species(ROS), Preeclampsia, Gestational Diabetes, Fetal Development