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Stone quarry activities in Nigeria are mostly unregulated such that the workers in these quarries are continuously exposed tothe inhalation of silica dust. It has been observed that silica dust particles negatively impact the health of stone quarry workerswhich usually manifest as respiratory difficulties, asthma-like illnesses and other adventitious events of the lungs. The study wasdesigned to evaluate the probable immunological impact of silica dust inhalation from stone crushing by workers. Blood sampleswere collected from consenting workers and analyzed for total white blood cells and their subsets. Absolute CD4 cells numberswere also determined. The results indicated that neutrophils and eosinophils numbers increased significantly (P < .05) and CD4counts declined significantly (P < .001). Alteration in these proportions is a pointer to the injurious impact of silica dust on theimmune system of these workers. The findings in this study should spur actions in the education of these workers on the need forthe use of proper personal protection equipment and the establishment of a scheme to periodically carry out a health assessmentcheck to identity those at most risk of developing chronic illnesses