Publications

Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.

2024 School of Allied Health Sciences Haematology International Journal

Antiretroviral Therapy and Red Blood Cell Morphology: A Review in HIV Patients

Emmanuel Ifeanyi Obeagu1*, Getrude Uzoma Obeagu2 and Matthew Chibunna Igwe3

Antiretroviral therapy (ART) has transformed the management of HIV, significantly improving the prognosis and quality of lifefor individuals living with the virus. While the primary focus of ART has traditionally been on viral suppression and immunerestoration, emerging evidence suggests a potential impact on red blood cell (RBC) morphology. This paper explores theintricate relationship between antiretroviral therapy and red blood cell morphology in HIV patients, shedding light on themultifaceted effects of these medications beyond their antiviral properties. Moving beyond laboratory findings, the reviewinvestigates the clinical implications of alterations in red blood cell morphology in individuals undergoing antiretroviral therapy.This includes discussions on potential implications for oxygen-carrying capacity, hemoglobin levels, and overall hematologicalhealth, emphasizing the need for a holistic understanding of the hematopoietic consequences of ART. In conclusion, this paperconsolidates existing knowledge, identifies gaps in understanding, and provides a comprehensive resource for researchers,clinicians, and healthcare professionals involved in the care of HIV patients. It contributes to the broader conversation on theholistic effects of antiretroviral therapy, paving the way for future investigations and improved clinical management