Publications

Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.

2024 School of Allied Health Sciences Virology & Immunology Journal

Immunological Challenges in Infants Living with HIV: A Review

Obeagu EI1* and Obeagu GU2

This paper explores the intricate immunological challenges encountered by infants living with Human ImmunodeficiencyVirus (HIV). The vulnerability of the developing immune system in early life, coupled with the unique characteristics of HIV,presents a complex scenario that impacts the health and well-being of these infants. Key areas of focus include the disruptionof immune system development, viral persistence mechanisms, consequences of chronic immune activation, and theincreased susceptibility to opportunistic infections. The paper also discusses current therapeutic interventions, emphasizingthe significance of early antiretroviral therapy (ART) initiation and emerging strategies aimed at improving immunologicaloutcomes. Insights into the maternal-fetal interface and preventive measures are explored, providing a holistic perspectiveon addressing the challenges faced by infants born with HIV. This comprehensive analysis aims to contribute to a deeperunderstanding of the immunological landscape in this vulnerable population and guide future research and interventions forenhanced patient care.