Publications

Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.

2024 School of Allied Health Sciences Haematology International Journal

Neutrophil Responses in Gestational Diabetes: A Cellular Ballet

Emmanuel Ifeanyi Obeagu1* and Getrude Uzoma Obeagu2

Gestational diabetes mellitus (GDM) introduces distinctive challenges to the maternal immune system, orchestrating a complexinterplay with the pivotal cellular dancers, neutrophils. This review delves into the dynamic world of neutrophil responsesduring gestational diabetes, portraying a cellular ballet influenced by factors such as oxidative stress, cytokine modulation,and their repercussions on both maternal and fetal health. The review amalgamates existing literature to provide a nuancedunderstanding of the intricate dance of neutrophils in the context of gestational diabetes. The review delves into the uniquecellular dynamics at the maternal-fetal interface, shedding light on how neutrophils contribute to the immune homeostasiscrucial for a healthy pregnancy. The article concludes by discussing clinical implications and potential therapeutic strategies tonavigate the intricate cellular ballet, offering insights for future research and intervention in the realm of gestational diabetesand immune modulation during pregnancy.