Publications

In the realm of global health diplomacy, diabetes mellitus undoubtedly poses a significant challenge. Furthermore,there is a pressing need to explore alternative and complementary therapies. Phytochemicals, which are naturallyoccurring bioactive compounds found in plants, exhibit distinct biochemical properties, rendering them promisingcandidates for diabetes management. This review focuses on the potential of various classes of phytochemicals,including polyphenols, alkaloids, terpenoids, organosulfur compounds, and polysaccharides, in diabetesmanagement. Each class demonstrates unique mechanisms of action, contributing to therapeutic effects such asenhancing insulin sensitivity, reducing carbohydrate digestion and glucose absorption, regulating antioxidantstress, inflammation, and glucose metabolism. While successful preclinical trials provide valuable insights, furtherrigorous clinical trials are imperative to ascertain the therapeutic efficacy, optimal dosage, bioavailability, andpotential interactions with concomitant medications. Understanding the functional pathways of plant-derivedsubstances is crucial, as it enables the formulation of precise strategies for incorporating them as dietary supplementsfor individuals with diabetes mellitus.Keywords: Phytochemicals, diabetes mellitus, insulin sensitivity, glucose metabolism, oxidative stress, andinflammation