Publications

The effect of root bark extract of Rauwolfia vomitoria (RV) and Vitamin E on neurobehaviour in 3-nitropropionic acid induced oxidative stress (OS) in mice was evaluated. Forty mice were divided into four groups (1-4) of 10 mice each. Animals in group one (control rats) received placebo treatment. Animals in group two were induced into oxidative stress by intraperitoneal injection (i.p) with 20 mg/kg body weight of 3-nitropropionic acid (3NP) once daily for 5 days. Animals in group three were pre-treated orally with 16 mg/kg body weight of root bark extract of R. vomitoria before being treated with 20 mg/kg body weight of 3NP (i.p) for 15 days. Animals in group four were pre-treated orally with 10mg/100g of Vitamin E (VE) before being treated with 20 mg/kg body weight of 3NP (i.p). The Morris water maze (MWM) test was done to determine the learning and memory status of the mice. There was significant (P