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2014 Faculty of Biomedical Sciences American Journal of BioScience

Hypoglycaemic potentials of frog oil in alloxan-induced diabetic rats

Osheke Shekins Okere, Moses Dele Adams, Uju Dorathy Ejike, Eunice Ogunwole, Ejike Daniel Eze

The hypoglycaemic potentials of frog oil in alloxan-induced diabetic rats were investigated. Thirty six male albino rats weighing 120.47±2.52 g was completely randomized into six groups (A-F) comprising 6 animals each. Animals in group A (control) were administered 1 ml of distilled water while those in groups B, C, D, E and F were induced with diabetes mellitus by intraperitoneal administration of alloxan monohydrate (180mg/kg body weight) and in addition were respectively administered distilled water, metformin (a reference antidiabetic drug), 3, 6 and 9 mg/kg body weight of frog oil once daily. Treatment with the oil lasted for 14 days during which blood glucose level and selected biochemical parameters were determined. The results showed that there was significant (p