Publications

Background: Diabetes is considered the third leading cause of death around the globe with a projection increase of its prevalence by 2030. Aim: The study was aimed at investigating the anti-diabetic and safety properties of aqueous extract of Vitellaria paradoxa (VPX) stem bark in streptozotocin-induced diabetic rats. Materials and methods: A total of thirty (30) albino rats weighing 150 ± 40.5 g were randomized into six groups (A-F). Group A (Control) are non-diabetic while group(s) B-F were made diabetic following administration of streptozotocin (90mg/kg body weight, i.p.) after which animals in groups C-F were administered 2.5 mg/kg b.w glibenclamide (reference drug), 80, 400 and 800mg/kg body weight of the extract respectively once daily for 21 days whereas animals in group(s) A and B received 0.5ml of distilled water orally. Blood sugar level, antioxidant enzyme status (catalase and superoxide dismutase), anti-dyslipidemic and kidney function parameters were determined in the experimental rats. Results: The results showed that aqueous extract of V. paradoxa stem bark produced a significant reduction (p