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Herbal medicines, including Kabuuti cough syrup, have gained popularity in treating various ailments, yettheir safety and efficacy require scientific scrutiny. This study aimed to evaluate the hematological andbiochemical effects of Kabuuti herbal cough syrup after 28 days of oral administration in Wistar rats. Theherbal extracts, containing secondary metabolites like terpenes, alkaloids, steroids, and phenols, wereadministered at different doses to rats, with distilled water as a control. Hematological and biochemicalparameters were assessed, showing no statistically significant changes in most parameters. However, therewere decreases in mean corpuscular volume (MCV) levels and lymphocyte percentage, and increases inhemoglobin (HB) levels and gamma glutamyl transferase (GGT) levels observed in certain dosage groups.Despite these variations, the overall findings suggest that Kabuuti herbal cough syrup is safe for liver andkidney function in the short term, with no significant adverse effects observed.Keywords: Kabuuti Cough Herbal