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2024 School of Pharmacy IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS

Evaluation of Musa acuminata Starch as a Diluent in Paracetamol Tablet Formulations

Tansah Mbunwe

Tablet formulation, a widely used dosage form, relies on excipients like diluents to ensure product quality. Thisstudy investigates the potential of Musa acuminata (matoke banana) starch as a diluent in paracetamol tablets.Starch was extracted from matoke bananas and formulated into three batches using wet granulation, withconcentrations of 5%, 10%, and 15% w/w. Comparative analysis was conducted with maize starch. Physiochemicalproperties of starch and granules, as well as tablet characteristics, were evaluated. Results indicated comparableproperties between matoke and maize starches. Tablets formulated with matoke starch exhibited optimaldisintegration time, hardness, friability, and weight uniformity, suggesting its potential as a cost-effective andaccessible alternative diluent