Publications

Depression and anxiety are prevalent co-morbidities among individuals with chronic alcohol consumption,posing significant health challenges worldwide. This study aimed to explore the potential protective effectsof a tryptophan-based diet against depressive tendencies and anxiety associated with chronic alcoholconsumption. Using an experimental design, Wistar rats were subjected to chronic alcohol administrationalong with varying doses of a tryptophan-based diet over 28 days. Behavioral tests including the ElevatedPlus Maze (EPM) and Forced Swim Test (FST) were conducted to evaluate anxiety-like behavior anddepressive tendencies, respectively. Results indicated a significant decrease in immobility time in the FSTwith increasing doses of the tryptophan-based diet, suggesting antidepressant effects. Moreover, the anxietyindex decreased while the time spent on open arms increased with higher doses of the diet in the EPM,indicating anxiolytic effects. These findings suggest that a high tryptophan-based diet could serve as apotential intervention for individuals with alcohol-related depression and anxiety