Publications

Protective activity on biochemical parameters and possible mechanisms of action of palm oil extracts wereinvestigated in orally Dichlorvos poisoned rats and the efficacy of treatments in the poisoned rats. Thesafety profile of the extracts was evaluated via acute toxicity studies which was done in two phases. Toscreen for phytochemicals, present in this extract. This study was carried out in Pharmacy and KIUTHlaboratories, Kampala International University, Uganda. Wistar rats of both sexes, weighing 85g andabove were used for the study. Selection of rats was done by simple random sampling. At the end of theadministration, plasma biochemical parameters were measured as indices of organ toxicity. The red palmoil used in treatment of Dichlorvos poisoned rats caused a reduction in concentration of some of thebiochemical parameters of the rats when given simultaneously compared to the kernel oil combinations.Administration of palm oil does not have prophylactic effect against the poison. However, it does seem tohave similar protective effects against oxidative stress with ascorbic acid. In summary the administrationof palm oil seemed to have limited ameliorative role against Dichlorvos poisoning in rats.Keywords: Dichlorvos, palm oil, palm kernel oil, rats, acute toxicity, oxidative stress