Role of L-selectin in Tuberculosis-HIV Coinfection: Implications for Immune Activation and Dysfunction
Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) coinfection pose significant challenges to global health, with intricate interactions between these pathogens influencing immune responses and disease outcomes. L-selectin, a cell adhesion molecule crucial for leukocyte trafficking and immune surveillance, has emerged as a key player in the pathogenesis of TB-HIV coinfection. This review explores the role of L-selectin in TB-HIV coinfection, focusing on its implications for immune activation and dysfunction. We discuss the modulation of L-selectin expression and function by TB and HIV, as well as its impact on immune responses, disease progression, and therapeutic strategies. Understanding the role of L-selectin in TB-HIV coinfection provides insights into disease pathogenesis and highlights opportunities for targeted interventions to improve patient outcomes.