Interplay between Liver, Kidney, and Heart in Metabolic Regulation and Cardioprotection: Mechanisms and Implications for Therapeutic Strategies
The intricate interplay between the liver, kidney, and heart in metabolic regulation and cardioprotectionis a topic of growing interest, particularly in the context of rising cardiovascular disease prevalence. Thispaper explores the dynamic interactions among these organs, highlighting their roles in energymetabolism, inflammation, and cardiovascular health. We discuss the mechanisms through which liverand kidney function impact cardioprotective properties, including the regulation of glucose and lipidmetabolism, inflammation modulation, and remote conditioning effects. Furthermore, we examine theimplications of liver-kidney-heart cross-talk for therapeutic strategies targeting cardiometabolicdisorders. Understanding these complex interactions is essential for the development of innovativetreatments to mitigate the burden of cardiovascular disease