2024 School of Pharmacy RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES The Role of Pharmacogenomics in Personalized Medicine: Historical Context, Principles, Applications, and Future Challenges 1Joseph Obiezu Chukwujekwu Ezeonwumelu, 2Uhama Kingsley Chukwuka, 3Ugwu Okechukwu Paul-Chima, 3Alum Esther Ugo, 4Ugwuanyi Anthony Chukwudi and 5Tambwe Patrick Rodrigue