Publications

Introduction: Patients with asthma are known with increased hospital visits and sudden deaths. Aim. The study was done toevaluate the changes in hematological parameters and inflammatory markers of patients with asthma in KIU-TH, Ishaka, Uganda.Methods: A total of 150 subjects were selected for the study comprising of 75 patients with asthma and 75 apparently healthyindividuals from Ishaka, Bushenyi District attending KIU-TH.Results: The results showed increase in total white blood cell count (P=0.000), Neutrophil (P=0.000) and no significant differencein Lymphocytes (P=0.406) of patients with asthma compared to apparently healthy individuals respectively. The results showedincrease in hemoglobin (P=0.004), red blood cells (P=0.015), Packed Cell Volume (P=0.009), Mean Cell Volume (P=0.000), RedCell Distribution Width (P=0.004) and decrease in MCHC (P=0.004) of patients with asthma compared to apparently healthyindividuals respectively. The results showed increase in NLR (P=0.039), PDW (P=0.010), PCT (P=0.002), decrease in platelets(P=0.021), MPV (P=0.031) and no significant difference in PLR (P=0.066) in patients with asthma compared with the apparentlyhealthy individuals respectively.Conclusions: The study revealed increase in total white cell count (WBC), neutrophils and reduced levels of cell lines. It showsserious immunological alterations in the patients with asthma. The inflammatory markers as NLR and PLR were increased whichshowed increased inflammation in the patients with asthma. These indicators could be used to predict the severity of the diseaseand as well in improvement as regards prognosis of the patients.