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High malaria burden has led to the increase use of insecticides in the tropics and subtropics. This study thus aimed atassessing the effect of insecticides inhalation on some haematological parameters using experimental animalmodel.Sixteen adult male rabbits divided into four groups A, B, C and D. Group A,B and C were exposed to 20ml ofpyrethroid insecticides containing 0.05% pralletrin and 0.15% cyfluthrin by inhalation for 10mins,20mins, and30mins respectively. Group D serve as the control and was not exposed. Baseline study was done on all the animalsbefore grouping for exposure. The pyrethroid insecticides was soaked in cotton wool (2.5g) in a container that wasable to prevent the animal from ingesting it, which was placed inside the room A, B and C for 10mins,20mins and30mins respectively. The rabbits were exposed for three weeks and sample were collected at the end of each week.Exposure was discontinued after day 21and Samples were collected again on day 28 and 35 respectively which is thefourth and fifth week. All the animals were monitored twice daily for clinical signs like jerky movement, skinscratching, licking of legs and other body parts. Data analysis revealed that there wassignificant effect of inhalation ofinsecticides on some haematological parameters of rabbits at 10min, 20mins and 30mins of exposure. There weresignificant increase in PCV, Eosinophil Platelets WBC and Neutrophil and decreased in ESR, Lymphocyte. Theresults from this study have shown that aerosol of these pyrethroid insecticides(pralletrin and cyfluthrin) has effecton haematological parameters. It is thus recommended that one should avoid exposure to the aerosol of these