Publications

Inflammatory state could play a role in the alterations of circadian rhythm of blood pressure (BP). This study wasaimed to evaluate the association of acute phase proteins with dippers and non-dippers blood pressure profile inpatients with new onset hypertension. A case control study involving a total of 50 subjects within the age range of30 to 60 years were recruited. Twenty five (25) subjects had incident blood pressure, while twenty five (25) werenormotensive who served as control. The subjects daytime and nocturnal blood pressure were taken a day to thesample collection. Blood samples collected were used in the assay of acute phase proteins; C-reactive protein,fibrinogen, ferritin and haptoglobin using standard ELIZA laboratory procedures. All data obtained in the studywere analyzed using student t-test (spss.21) and Pearson correlation coefficient. The level of significance was set atp < 0.05. There was no significant difference (p=0.393) in the mean value of CRP in dipper subjects(1.94±0.60)mg/ml when compared to non-dipper subjects (2.23±0.91)mg/ml. There was no significant difference(p=0.288) in the mean value of fibrinogen in dipper subjects (3.72±1.01)mmol/L when compared to healthy nondipper subjects (4.19±0.94)mmol/L. There was no significant difference (p=0.116) in the mean value of ferritin indipper subjects (2.63±0.39)mg/L when compared to healthy non dipper subjects (2.95±0.49)mg/L. There was nosignificant difference (0.419) in the mean value of Haptoglobin in dipper subjects (1.17±0.28)g/L when compared tohealthy non dipper subjects (1.28±0.32)g/L. The mean value of C-reactive protein was significantly reduced(p=0.002) in hypertensive dipper subjects (3.11±1.39)mg/ml when compared to hypertensive non dipper subjects(6.14±2.20)mg/ml. The mean value of fibrinogen was significantly reduced (p=0.018) in hypertensive dippersubjects (5.32±1.11)mmol/L when compared to hypertensive non dipper subjects (7.04±1.71)mmol/L. There wasno significant difference (p=0.067) in the mean value of ferritin in hypertensive dipper subjects (3.51±0.59)mg/Lwhen compared to hypertensive non dipper subjects (4.13±0.78)mgl/L. There was no significant difference (0.239)in the mean value of Haptoglobin in hypertensive dipper subjects (2.25±1.11)g/L when compared to hypertensivenon dipper subjects (2.90±1.21)mgl/L. The mean value of C-reactive protein was significantly increased (p=0.019)in hypertensive dipper subjects (3.11±1.39)mg/ml when compared to non-dipper subjects (1.94±0.60)mg/ml. Themean value of fibrinogen was significantly increased (p=0.003) in hypertensive dipper subjects (5.32±1.11)mmol/Lwhen compared to non-dipper subjects (3.72±1.01)mmol/L. Non dipper variation in high blood pressure isassociated with increase in C-reactive protein, fibrinogen, ferritin and haptoglobin. But there is no significantdifference in acute phase inflammatory proteins in healthy dipper when compared to healthy non dippers.