Publications

This study was aimed at evaluating the association of acute phase protein with diurnal variation of blood pressureamong healthy pre and post-menopausal women. The study population consisted of 40 postmenopausal women andpremenopausal women (Control). Blood samples collected were used in the assay of acute phase proteins. C-reactiveprotein, fibrinogen, ferritin and haptoglobin was determined using standard laboratory procedures. All data obtainedin the study were analyzed using student t-test (spss.21). The level of significance was set at p < 0.05. The meanvalue of systole was significantly increased (p=0.001) in Nornotensive menopausal women (126.30±6.63) mmHgwhen compared to normotensive premenopausal women (116.60±4.33) mmHg. The mean value of diastole wassignificantly increased (p=0.000) in normotensive menopausal women (77.20±5.51) mmHg when compared tonormotensive premenopausal women (68.40±3.37) mmHg. The mean value of C-reactive protein was significantlyincreased (p=0.002) in normotensive menopausal women (3.04±0.74)ng/ml when compared to normotensivepremenopausal women (1.99±0.55)ng/ml. The mean value of haptoglobin was significantly increased (p=0.037) innormotensive menopausal women (2.08±1.15)g/L when compared to normotensive premenopausal women(1.24±0.26)g/L. There was no significant difference (p=0.525) in the mean value of fibrinogen in normotensivemenopausal women (3.53±0.87)nmol/L when compared to normotensive premenopausal women(3.81±1.02)nmol/L. There was no significant difference (p=0.299) in the mean value of ferritin in normotensivemenopausal women (2.95±0.59)ng/L when compared to normotensive premenopausal women (2.69±0.48)ng/L.The mean value of C-reactive protein was significantly increased (p=0.000) in hypertensive menopausal women(4.31±0.85)ng/ml when compared to normotensive premenopausal women (1.99±0.55)ng/ml. The mean value offibrinogen was significantly increased (p=0.038) in hypertensive menopausal women (4.89±1.13)nmol/L whencompared to normotensive premenopausal women (3.81±1.02)g/L. The mean value of haptoglobin was significantlyincreased (p=0.000) in hypertensive menopausal women (2.95±1.24)gl/L when compared to normotensivepremenopausal women (1.24±0.26)g/L. The mean value of ferritin was significantly increased (p=0.021) inhypertensive menopausal women (3.30±0.59)ng/L when compared to normotensive premenopausal women(2.69±0.48)ng/L. The mean value of C-reactive protein was significantly increased (p=0.002) in hypertensivemenopausal women (4.31±0.85)ng/ml when compared to normotensive menopausal women (3.04±0.74)ng/ml. Themean value of fibrinogen was significantly increased (p=0.008) in hypertensive menopausal women(4.89±1.13)nmol/L when compared to normotensive menopausal women (3.53±0.87)mmol/L. There was no significant difference (p=0.122) in the mean value of haptoglobin in hypertensive menopausal women(2.95±1.24)gl/L when compared to normotensive menopausal women (2.08±1.15)g/L. There was no significantdifference (p=0.204) in the mean value of ferritin in hypertensive menopausal women (3.30±0.59)ngl/L whencompared to normotensive menopausal women (2.95±0.59)ng/L. From the study, Menopausal women with highblood pressure presented with significant increase in C-reactive protein, fibrinogen, haptoglobin and ferritin.