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Sickle cell anemia is associated with recurrent multi-organ ischemia and infarction. This study was aimed atdetermining the level of the markers of myocardial infarction and atherogenicity in subjects with sickle cell trait. Atotal of 30 subjects were recruited for the study of which 10 were subjects with HbAS, 10 were subjects with HbSSwhile 10 were healthy subjects. Five (5mls) of fresh venous blood was collected from all the participants byvenepuncture using sterile needle and syringe. Lipid profile, aspartate amino transferase, lactate dehydrogenase andtroponin were determined using enzymatic method while troponin was determined using ELISA method. All valueswere expressed as mean ± standard deviation. The statistical analysis was carried out using ANOVA. Values withlevel of significance (p<0.05) was considered to be statistically significant. There was a significant increase (p=0.014,p=0.000, p=0.000, p=0.000 respectively) in the mean values of triglyceride (127.5±31.21)mg/dl, lactatedehydrogenase (692±152.68)u/l, troponin (2.35±0.59)ng/ml and aspartate amino transferase (67.9±16.59)ug/ml inHbSS subjects compared to control subjects (95.92±22.79)mg/dl, (378.10±105.72)U/L, (0.11±0.06)ng/ml and(18.9±4.95) respectively. The mean value of T Chol, HDL and LDL were significantly reduced (p=0.000, p=0.001,p=0.000 respectively) in HbSS subjects (172.68±14.82)mg/dl, (60.75±7.12)mg/dl and (91.55±16.55)ug/ml whencompared to control subjects total cholesterol (129.03±37.62)mg/dl, high density lipoprotein (41.10±10.85)mg/dland low density lipoprotein (69.06±10.54)mg/dl. There was a significant increase (p=0.002, p=0.000, and p=0.006respectively) in the mean value of lactate dehydrogenase (515.60±62.39)U/L, troponin (1.29±0.76)ng/ml andaspartate amino transferase (25.50±7.32)U/L in HbAS subjects compared to control subjects (378.10±105.72)U/L,(0.11±0.06)ng/ml and (18.9±4.95)U/L respectively. The mean value of total cholesterol and high densitylipoprotein were significantly reduced (p=0.001 and p=0.009 respectively) in HbAS subjects (153.49±9.13)mg/dland (52.45±5.99)mg/dl when compared to control subjects total cholesterol (172.68±14.82)mg/dl and high densitylipoprotein (60.75±7.12)mg/dl. The mean value of triglyceride and low density lipoprotein showed no significantdifference (p=0.448 and p=0.192) in HbAS subjects (94.27±21.47)mg/dl and (86.52±9.87)mg/dl when compared tocontrol subjects (95.92±22.79)mg/dl and (91.55±16.55)mg/dl. There was a significant increase (p=0.001, p=0.011,p=0.002 respectively) in the mean value of total cholesterol (153.49±9.13)mg/dl, high density lipoprotein(52.45±5.99)mg/dl and low density lipoprotein (86.52±9.87)mg/dl in HbAS subjects when compared to HbSSsubjects (129.03±37.62)mg/dl, (41.10±10.85)mg/dl and (69.06±10.54)mg/dl respectively. The mean value ofTriglyceride, Lactate Dehydrogenase, Troponin and Aspartate Amino Transferase were significantly reduced(p=0.002, p=0.005, p=0.002 and p=0.000 respectively) in HbAS Patients (94.27±21.47)mg/dl, (515.60±62.39)u/l,(1.29±0.76)ng/ml and (25.50±7.32)u/L when compared to HbSS subjects (127.5±31.21)mg/dl, (692±152.68)u/l,(2.35±0.59)ng/ml and (67.9±16.59)u/l. Though there were some differences in the individual results, sickle celldisease is associated with increased level of triglyceride, lactate dehydrogenase, troponin and aspartate aminotransferase and a decreased level of T Chol, HDL and LDL. From these results, there is a clear indication ofderangement of lipid metabolism and dyslipidaemia, which suggest association of sickle cell disease withcardiovascular diseases