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This study was carried out in Kampala International University Teaching Hospital, BushenyiDistrict with the purpose of identifying the factors affecting the utilization of insecticidetreatedmosquito nets (ITNs) among pregnant mothers. A descriptive and cross-sectionaldesign was employed and 60 (sixty) respondents were selected using a convenient samplingmethod. Data was collected using a questionnaire. The study found that respondents facedvarious social factors affecting the utilization of ITNs among pregnant mothers and althoughall the respondents 60 (100%) had heard of ITNs and 60 (100%) understood ITNs as aninsecticide-treated bed net that prevents mosquito bites, the majority of respondents 40(66.7%) did not own an ITN while the majority 40 (66.7%) reported that they only sometimesslept under an ITN every night due to various factors including 14 (26.9%) causing too muchheat, 12 (23.2%) said ITNs made it difficult to breathe, 8 (15.4%) disturbed to put up and downevery night while 6 (11.5%) said it contained dangerous chemicals. In conclusion, theresearcher noted that respondents faced various factors affecting the utilization of ITNamong pregnant mothers and this hence required immediate intervention to put preventivemeasures in practice and reduce the spread of malaria among pregnant mothers in the studysetting