Publications

Cancer remains a leading global cause of morbidity and mortality, prompting the exploration of preventive strategies beyond conventional treatments. Cancer chemoprevention, which involves the use of natural or synthetic agents to impede, delay, or reverse carcinogenesis, has gained significant attention, particularly through the study of plant-derived compounds. Phytochemicals such as curcumin, resveratrol, epigallocatechin gallate (EGCG), quercetin, and sulforaphane have demonstrated diverse mechanisms of action, including antioxidant and anti-inflammatory effects, modulation of enzyme activity, regulation of signaling pathways, and induction of apoptosis. Epidemiological and preclinical studies highlight the contribution of fruits, vegetables, herbs, spices, legumes, and nuts to reduced cancer risk, supported by the presence of bioactive compounds with chemopreventive potential. Clinical investigations, especially on curcumin, resveratrol, and EGCG, provide evidence of efficacy, although challenges such as poor bioavailability, lack of standardization, and regulatory hurdles persist. Advances in nanotechnology, extract standardization, and multidisciplinary collaborations offer promising strategies to overcome these barriers. Collectively, the integration of plant-derived compounds into preventive and therapeutic approaches underscores their potential in reducing cancer incidence and improving global health outcomes.