Publications

Urinary tract infections (UTI) remain a global health dilemma and it accounts for the majorityof reasons for hospital visiting globally. Sound knowledge of factors associated with UTI mayallow timely intervention that can easily bring the disease under control. The aim of thisstudy was to evaluate the common urinary tract infection causing pathogens isolated amongUTI patients with the common prescribed antibiotics and to establish multiple antibioticresistance patterns to commonly prescribed antibiotics among patients with urinary tractinfections attending KIU-TH and Ishaka Adventist Hospital during period from August 2018to July 2019 in Bushenyi district of Uganda. In this cross-sectional study, 106 (54 femalesand 52 males) UTI patients were obtained from KIU-TH while 108 (68 females and 40 males)UTI patients were obtained from Ishaka Adventist hospital using microbiological laboratoryresults and medical records. Data generated were tested for statistical significance andscientific relevance. In KIU-TH, Escherichia coli was the most common isolated bacterialpathogen with 46/106 (43.4%) followed by Staphylococcus aureus 34/106 (32.1%). Klebsiellapneumoniae 20/86 (18.9%), Pseudomonas species 4/106 (3.8%), Proteus species 1/106 (0.9%)and Coccobacilli species 1/106 (0.9%). In Ishaka Adventist Hospital, Escherichia coli was alsomostly isolated with 51/108(47.2) followed by Staphylococcus aureus 27/108 (25.0%). Proteusspecies 12/108 (11.1%), Pseudomonas species 11/108(10.2), Klebsiella pneumoniae7/108(6.5%). This study revealed that Azithromycin was the most prescribed antibiotic inIshaka Adventist with 18.3% while Ciprofloxacin was the most prescribed antibiotic with19.4% in KIU-TH. E. coli species showed 5.8% resistance to Azithromycin while otherpathogens did not show any resistance to it in Ishaka Adventist Hospital. E. coli had 33.3%resistance to Ciprofloxacin followed by S.aureus with 23.5%, Klebsiella species 20.0%, Proteusspecies 100% while Pseudomonas species and Coccobacilli species showed no resistance inKIU-TH. This study also demonstrated that in KIU-TH the age <30 had statistically significantrelationships (p<0.05) with UTI Bacteria while marital status, occupation, gender and religionwere not statistically significant (P>0.05). In Ishaka Adventist Hospital, no socio-demographicfactor was statistically significant (P>0.05). In conclusion, Age≥30 significantly (p<0.05) influenced UTI distribution in KIU-TH. Resistance to Azithromycin and Ciprofloxacin may affect their use in UTI management. Antibacterial misuse is highly discouraged.