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Background: Tis study investigated the efect of the extractable hypoglycaemic principles from Securidaca longepedunculata leaves on some biochemical parameters in alloxan-induced diabetic rats with the view to having improvedpharmacological agent(s) that could be used in managing diabetes mellitus with relatively lesser side efects. Tree groupsof four rats each were used for the oral glucose tolerance test (OGTT): group one received 3mL/kg BW normal saline(normal control) while groups 2 and 3 received 200 and 400mg/kg BW of methanol extract of Securidaca longepedunculata (MESL), respectively. Six groups of fve rats per group were used for the main antidiabetic study. Group onereceived 3mL/kg BW normal saline (normal control), group 2 received no treatment after induction, group 3, received5mg/kg BWglibenclamide (standard group), groups 3–6 received 100, 200, and 400mg/kg BW MESL, respectively, afterinduction.Results: Te OGTTshowedsignifcant (p<0.05) reduction in random blood sugar of the treated groups compared to the control.In the antidiabetic study, the treated groups 4–6 signifcantly (p<0.05) lowered the blood glucose of the Wistar rats compared tothe treatment control. Extract administration showed no adversity to liver and kidney, respectively, as shown by result of testedstandard indicators. Equally MESL caused signifcant (p<0.05) increase in serum antioxidant activities and signifcant (p<0.05)decrease in malondialdehyde concentration compared to the treatment control.Conclusion: Te study suggested hypoglycaemic potency, antioxidant rejuvenation, and relative hepatic and nephron safetyby MESL.