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Alcohol is the most commonly used psychoactive substance and, globally, causes 1.8 million or 3.2% of all deathsand accounts for 4.0% of the disease burden (WHO, 2007). To determine the prevalence of alcohol use disordersamong medical students at KIU-WC Ishaka town, Bushenyi district Uganda. This was a descriptive cross-sectionalstudy conducted to explore the factors influencing alcohol use disorder among medical students at KIU-WC Ishaka-Bushenyi district. The quantitative strategy was used to tabulate numerical data which was presented in pie charts,graphs and tables. Most respondents 45(37.5) were in the age group of 21-23 years and the lowest 12(10%) in theage group of 18-20 years, 75(62.5%) were males and the least 45(37.5%) were females, 35(29.2%) were Baganda withleast 15(12.5%) were Iteso. The biggest respondents 45 (37.5%) were Catholics while least 2(1.7%) were Moslems,75(62.5%) were single while the least 3(2.5%) were divorced from their partners, 45(37.5%) were in BMS 3.1-3.2while the least of respondents 14(11.7%) were from BMS 4.1-4.2 and the biggest respondents 65(54.2%) were otherslike students while the least 10 (8.3%) were peasant farmers. From the study findings, 20.8% of the students werenot taking alcohol, 79.2% were drinking alcohol, 79.2% and 65% were drinking alcohol harmfully and hazardouslywhile were alcohol dependent. The major contributing factor to alcohol abuse among KIU-WC medical studentswas social environmental which included stress, peer pressure and social norms. The second contributing factor wasenvironmental like availability, persuasive adverts and local breweries and economic factors like unemployment, lossof job, and high-income status being the least contributing factors