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Diarrhea is among the top ten killers and causes 11% of child deaths globally. According to WHO, diarrhea deathsin children under five reach 525,000 and children global diarrhea cases was 1.7 billion every year. In Uganda,diarrhea is among the top four leading direct causes of morbidity and mortality in infants and under five childrenfollowing malaria, neonatal diseases and pneumonia. The objectives of this study were to assess water, sanitationand nutrition factors associated with diarrhea among children under five years of age in Kijumo Village, BushenyiDistrict. This study employed a descriptive cross sectional study design that employed quantitative approach fordata collection. A semi-structured questionnaire was used to collect information from 130 respondents. Data wasanalyzed using EPI info (exe) version 7 computer statistical package in order to give a statistical meaning to thedata. Out of 130 children under five years, 38 had diarrhea two weeks before the interview, given a prevalence of29.2%. The factors associated with diarrhea among children under five years. The results indicates that age ofrespondents was associated (p<0.001) with diarrhea; education level (p<0.002) and the child’s age (p<0.001) wasalso associated with diarrhea. Drinking water source (p<0.002), drinking water treatment (p<0.001), refuse disposal(p<0.002) and stool disposal (p<0.002) were associated with diarrhea. Exclusive breastfeeding (p<0.001), age ofintroduction of complementary feeding (p<0.003) and mode of feeding the child (p<0.002) were associated withdiarrhea. The health care stakeholders should train, encourage and empower community health workers to providecontinuous health education to mothers on diarrhea prevention and control