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2023 School of Pharmacy EURASIAN EXPERIMENT JOURNAL OF BIOLOGICAL SCIENCES

Formulation and Evaluation of Ibuprofen Tablets Using Musa acuminata Starch as a Binder by Wet Granulation

Lailah Nakazibwe

The granule was evaluated and had fair flow properties using tests such as bulk density. Ibuprofen tablets of 400mgwere then formulated from granules by compression. The process of tableting was carried out at Mbarara Universityof science and technology using the Pharmbiotrac laboratories. The tablet properties such as friability test,disintegration test, hardness test was carried out and the results were fairly good. Unfortunately, only one Batchwas able to pass the dissolution test and all batches were not able to yield about 95% drug concentration on drugassay. The study's primary goal was to formulate tablets of ibuprofen where Musa acuminata starch is used as abinder using wet granulation method. The Musa acuminata starch was used to form a mucilage which was used as abinder in the formulation. Musa acuminata starch showed good binding properties, this is seen in the hardness test.The formulated tablets had a good crushing strength. The disintegration of the tablets was fair. But the batcheswere not able to pass the drug assay test, the tablets contained 80% of the active ingredient.Musa acuminata starchhas good physical properties and is a good binder and could be a competitor of corn starch as a binder howevercompatibility tests are required to prove its compatibility with active ingredient ibuprofen