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Uganda has seen an increase in diabetes cases as well. The incidence is 1.4%, however the Eastern Region has seenprevalence rates as high as 7.4%. As indicated by the insufficient (poor) diabetes care found particularly in ruralregions, the financial burden of diabetes is quite large and constantly growing, a burden that hurts the Ugandaneconomy. The goal of this study was to determine how common diabetes mellitus and its consequences are at HoimaRegional Referral Hospital. Using patient data who visited the hospital between January 2020 and December 2020,a facility-based retrospective cross-sectional study was carried out at the Hoima regional referral hospital in WesternUganda. The files that will be examined were selected using a straightforward random sample technique. MicrosoftExcel 13.0 was used to enter the data into the computer and STATA version 14.0 was used to analyze it. Thecomplications associated with diabetes mellitus were identified using bivariate logistic regression; odds ratios werepresented together with the 95% confidence interval p value, which indicated significance. Participants in the studywere 43.02 years old on average, with a standard deviation of 17.07 years. With an interquartile range of 29 to 56years, the median age was 40 years. At a 95% confidence interval of 19.46 to 29.49, the total prevalence of diabetesmellitus was 24.48% (70/286). The age group of 71 years had the highest prevalence of Diabetes Mellitus, with aprevalence of 36.36% at a 95% confidence interval of 14.53-58.19, while the age group of 51 to 60 years had thelowest prevalence, with 19.51% at a 95% confidence interval of 06.85-32.18. The research revealed that diabetesmellitus was linked to 4 sequelae, including cardiovascular disease (cOR 2.18, 95% CI 1.26-3.77, P=0.005) andneuropathy (cOR 2.31, 95% CI 1.31-4.06, P=0.004). Foot damage (cOR 23.82, 95%CI 11.98-47.35, P0.001) andretinopathy (cOR 1.91, 95%CI 1.05-3.48, P=0.034). At Hoima Regional Referral Hospital, the case fatality rate fordiabetes mellitus cases over the course of a year was 14.29%. Compared to the overall prevalence of diabetes mellitusin Uganda, the prevalence of the disease at Hoima Regional Referral Hospital is greater. By initiating diabeticpatients on anti-diabetics early enough, ensuring that they take the medication as prescribed, and providing themwith self-management advice, it is possible to prevent all complications of diabetes mellitus.