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Various communities in Uganda have historically utilized the leaves of Diospyros abyssinica to treat wounds, although,regarding its capability to treat wounds, there were no published scientific studies. To get around the drawbacks oftraditional medications, research into natural therapies for the treatment of wounds is necessary. The study'sobjective was to assess the in vivo effectiveness of a Diospyros abyssinica leaf extract from the Tooro botanical gardenson wounds in mice. The leaves of Diospyros abyssinica were cleaned, dried in the cooling shade, and milled into finedust. After that, they were macerated in eighty percent methanol for three days. The percentage of the wound'soriginal area that contracted was used to assess the healing process in incised wounds. Afterward, animals weredivided into 5 groups, caged and treated in their respective groups topically. Group 1 was treated with 25mg/mLof concentrated extract, group 2 with 50mg/mL of Diospyros abyssinica concentrated methanol extract, group 3 wastreated with 100mg/mL of Diospyros abyssinica methanol extract, group 4 with Vaseline (negative control), group 5with sulfadiazine 0.1% cream (positive control) until the wounds are fully healed. During wound treatment,100mg/ml of 80% methanolic crude extract Diospyros abyssinica leaves showed significant mean wound area (p<0.05)during days 2 to 6 and on days 10 to 14 evaluations, followed by 50mg/mL and 25mg/mL. The study's findingssupported previous claims by demonstrating that an 80% methanolic extract of Diospyros abyssinica leaves exhibitsdose-related wound healing efficacy