Information management has become important in most organizations including hospitals and health centers and this is because access to information and other resources have become easier due to improvement and developments especially in technology. The purpose of this study was to examine the infrastructure used in rural health centers in managing information and to ascertain how quality of information was maintained in rural health centers. The study was conducted in two health centers of Rubaare health center IV, and Rwashamire health center IV, in Ntungamo district in western Uganda, questionnaire were used in the target population of 50, and a sample size of 44. 41 questionnaires were returned and this gave a return rate of 93.2 %.The results showed that infrastructure for information management is available but there is need to improve on the numbers and the findings in maintaining the quality of information clearly demonstrated that the health centers were using the manual or paper based system for maintaining the quality of patient records. The respondents reported having very little computer knowledge and limited access to computers (mean=2.63) and internet services (Mean=2.49), which suggests a lack of necessary skills among the health workers. The respondents disagreed (mean=2.20), that the health centers use an electronic health records system for maintaining patient’s records. The study suggested that health centers use computers in managing patient records and maintaining the quality of information as this will help them ensure privacy of data, reduce errors. The health centers need to establish written policies, which dictate on the relevance of computer knowledge to health workers and its relevance to the performance, quality of patient’s information and have daily backups of the information