The aim of this study was to develop and validate a model for Integration of ICT in Tracking Administration of Malaria Drugs in Uganda for both health workers and health units. A descriptive and correlational research design were used. Descriptive statistics was used during data analysis, analytical approach was used for model development, and model validation employed experts’ knowledge technique. Findings: Model variables revealed strong and positive relationships, Controls, Intention and Actual use of ICT was weak. The controls strongly impacted ICT Integration, Intension and Actual Use of ICTs. Conclusion: model is communicative, relevant to the operations, understandable, adequate for tracking issues, improves rates of execution of malaria drugs information needs, cheap, accurate, reduces operational costs, worth adoption, and model positively support clinical activities.