Molecular mechanisms of HIV-1 latency reactivation in resting memory CD4+ T-lymphocytes from HIV patients on HAART.
Host mechanisms mediating HIV-discordance, elite suppression, long-term non-progression, fast disease progression and its implications in HIV vaccine research, design and development.
Transmissibility and prevalence of HIV-associated systemic and oral herpesviral And high-risk human papillomavirus infections among HIV-discordant couples
Joseph Francis Hokello, Ph.D: Dr. Joseph Hokello is a Senior Lecturer in the Basic Science Department and Faculty Research Coordinator for the Faculty of Science and Technology, Kampala International University, Western Campus. Dr. Hokello is a Molecular Virologist/Biologist with enormous research experience and expertise focusing on HIV biomedical research for HIV prevention in developing countries and globally. His research interest among others include understanding the contribution of transcription factors that are mobilized following T cell receptor activation in the reactivation of HIV latency in resting memory CD4+ T cells from patients on prolonged highly active antiretroviral therapy (HAART). Besides, Dr. Hokello is a Professional Science educator with pedagogical skills required to enhance teaching and comprehension of Science’s complex concepts.
Hokello J, Nguyen M and Tyagi M (2019). Molecular Biology of Human Immunodeficiency Virus type-1: Immunological evidence in support of male circumcision in the control of heterosexual virus transmission A Review, (In Preparation).
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Hokello J, Karn J and Tyagi M (2019). Efficient non-epigenetic activation of HIV latency by the T-cell receptor signalsome.
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Hokello J, and Karn J (2019). Activation of HIV latency in T-cells is regulated by complimentary MAPK and PKC signal pathways: Synergy between AP-1 and NF-κB enhances HIV transcriptional elongation.
Journal of Virology
Hokello J, Sharma AL, Dimria M and Tyagi M (2019). nsights into the HIV latency and the role of cytokines.
Pathogens
Kim YK, Mbonye U, Hokello J, and Karn J (2011). -cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway..
Journal of Molecular Biology,
Pearson R, Kim YK, Hokello J, Lassen K, Friedman J, Tyagi M, and Karn J (2008). Epigenetic silencing of human immunodeficiency virus transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV in to latency.
Journal of Virology
Kajumbula H, Wallace RG, Zong JC, Hokello J, Sussman N, Simms S, Rockwell RF, Pozos R, Hayward GS and Boto W (2006). Ugandan Kaposi’s sarcoma-associated herpesvirus phylogeny: evidence for cross-ethnic transmission of viral subtypes.
Intervirology
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Microbiology and Immunology
Applied Biology
Advanced Animal Physiology
Plant Physiology
Department of Basic Science/Computing Kampala International University P.O.BOX 71 Bushenyi,Uganda