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2024 School of Allied Health Sciences

GATA-1 and Inflammatory Signaling Pathways in HIV-Related Hematological Disorders: Mechanisms and Therapeutic Implications

Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of Medical Sciences | Pp. 27-44

Hematological disorders are common complications of HIV infection, characterized by immune dysregulation, chronic inflammation, and aberrant hematopoiesis. GATA-1, a critical transcription factor in hematopoiesis, has emerged as a key regulator of inflammator...

2024 School of Allied Health Sciences

Understanding the Molecular Basis of Deep Venous Thrombosis in HIV: The GATA-1 Perspective

Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of Medicine | Pp. 37-54

Deep venous thrombosis (DVT) represents a significant complication in individuals living with Human Immunodeficiency Virus (HIV), contributing to morbidity and mortality. While the pathogenesis of DVT in HIV is multifactorial, recent research has implicated d...

2024 School of Allied Health Sciences

Understanding the Role of GATA-1 in T-Cell Development in the Context of HIV Infection

Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of HIV | Pp. 18-34

T-cell dysfunction is a hallmark feature of HIV infection, contributing to disease progression and susceptibility to opportunistic infections. GATA-1, a key transcription factor traditionally associated with erythropoiesis, has emerged as a critical regulator...

2024 School of Allied Health Sciences

GATA-1 and Hematopoietic Stem Cell Quiescence in HIV: Implications for Therapy

*Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of Medicine | Pp. 19-36

Hematopoietic stem cell (HSC) quiescence is crucial for maintaining the regenerative capacity of the hematopoietic system, and dysregulation of HSC quiescence has been implicated in hematological disorders, including those associated with Human Immunodeficien...

2024 School of Allied Health Sciences

Citation: Obeagu EI, Obeagu GU. GATA-1 and HIV-Associated Myelodysplastic Syndromes: Pathogenesis and Treatment Strategies. Elite Journal of Medicine, 2024; 2(4): 1-18 1 GATA-1 and HIV-Associated Myelodysplastic Syndromes: Pathogenesis and Treatment Strategies

Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of Medicine. | Pp. 1-18

Myelodysplastic syndromes (MDS) pose a significant clinical challenge in individuals with Human Immunodeficiency Virus (HIV) infection, characterized by dysregulated hematopoiesis and an increased risk of progression to acute myeloid leukemia (AML). Emerging...

2024 School of Pharmacy

Understanding Caretakers' Treatment Facility Preferences for Children with Febrile Illnesses: Insights from Ishaka Town, Bushenyi District, Uganda

Ndugga Harrison

2024 | IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS | Pp. 60-69

This study was carried out to assess the factors that influence choice of treatment facility by the caretakers ofchildren with febrile illnesses in Ishaka town, Bushenyi district. A total of 50 questionnaires were issued torespondents after attaining their co...

2024 Faculty of Clinical Medicine and Dentistry

Socio-Economic and Demographic Determinants of Safe Sex Practices among Young Adults: Insights from Kampala International University, Western Campus

Ruhweza Fatma

2024 | NEWPORT INTERNATIONAL JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 19-37

This study aimed to assess young adults' knowledge and practices that affect safe sex behavior among university studentsin Uganda, with a particular focus on Kampala International University Western Campus. The study was conducted at theuniversity's Western C...

2024 Faculty of Science and Technology

Revolutionizing Coffee Farming: A Mobile App with GPS-Enabled Reporting for Rapid and Accurate On-Site Detection of Coffee Leaf Diseases Using Integrated Deep Learning

Eric Hitimana 1,* , Martin Kuradusenge 1 , Omar Janvier Sinayobye 1 , Chrysostome Ufitinema 2, Jane Mukamugema 2, Theoneste Murangira 3, Emmanuel Masabo 1, Peter Rwibasira 2 , Diane Aimee Ingabire 1, Simplice Niyonzima 1, Gaurav Bajpai 4, Simon Martin Mvuyekure 5 and Jackson Ngabonziza 6

2024 | MDPI Software | Pp. 146-168

Coffee leaf diseases are a significant challenge for coffee cultivation. They can reduce yields,impact bean quality, and necessitate costly disease management efforts. Manual monitoring is laborintensiveand time-consuming. This research introduces a pioneerin...

2024 School of Pharmacy

Protective Activity of Palm Oil Extracts against Dichlorvos Poisoning in Rats: Biochemical Parameters and Mechanisms of Action

Ashebiaram Confidence

2024 | IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS | Pp. 45-53

Protective activity on biochemical parameters and possible mechanisms of action of palm oil extracts wereinvestigated in orally Dichlorvos poisoned rats and the efficacy of treatments in the poisoned rats. Thesafety profile of the extracts was evaluated via a...

2024 Faculty of Clinical Medicine and Dentistry

Prevalence of Hypertension and Associated Factors among Patients Attending Hoima Regional Referral Hospital, Hoima District Western Uganda

Bagonza Nathern

2024 | IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS | Pp. 34-44

Hypertension is an important contributor to the global burden of disease and mortality, and is a growing publicconcern in the developing world but data on hypertension and its associated factors among populations in thedeveloping nations is minimal. However,...